Published February 2004
by New York Academy of Sciences .
Written in English
|Contributions||Bita Moghaddam (Editor), Marina E. Wolf (Editor)|
|The Physical Object|
|Number of Pages||487|
Problems in making or using glutamate have also been linked to a number of mental health disorders, including autism, schizophrenia, depression, and obsessive-compulsive disorder (OCD). Glutamate. Relationships between Glutamate Function and Positive Symptoms. Several studies have investigated associations between regional glutamatergic metabolite levels and the severity of positive psychotic symptoms (Table (Table1), 1), and most found no association between regional Glx, glutamate or glutamine levels and positive symptom severity, in either high genetic or clinical risk populations Cited by: INTRODUCTION. Mood disorders such as bipolar disorder (BPD) and major depressive disorder (MDD) are chronic, disabling psychiatric disorders generally associated with unfavorable outcome and impairment in diverse areas. 1 Indeed, the World Health Organization's (WHO) Global Burden of Disease projects that mood disorders will be the leading cause of disability worldwide within the next decade Cited by: The glutamate hypothesis of schizophrenia, proposed over two decades ago, originated following the observation that administration of drugs that block NMDA glutamate receptors, such as ketamine, could induce schizophrenia-like symptoms. Since then, this hypothesis has been extended to describe how glutamate abnormalities may disturb brain function and underpin psychotic symptoms Cited by:
The age of glutamate began with the discovery of metabotropic glutamate receptors in , which shortly became a promising alternative to iGlu receptors in a variety of investigations in the field of neuropharmacology (Nicoletti et al., ). Presently, the important role of mGlu receptors in anxiety is almost unquestioned and their role as Cited by: l-Glutamate is the most abundant of a group of endogenous amino acids in the mammalian central nervous system which presumably function as excitatory neurotransmitters and under abnormal conditions may behave as neurotoxins. As neurotransmitters, these compounds are thought to play an important role in functions of learning and memory. As neurotoxins, they are believed to be involved in Cited by: Glutamate is an amino acid with very different functions: in the pancreas, it modulates the activity of the pancreatic ß--cells responsible for insulin production, whereas in the brain it is the. Abstract: Glutamate, first identified in , is the primary excitatory neurotransmitter in the brain. While it is critically important in many highly regulated cortical functions such as learning and memory, glutamate can be much like the magic the Sorcerers Apprentice used in Goethes poem: when conjured under unregulated conditions glutamate can get quickly out of control and lead to.
Anxiety, stress, and trauma-related disorders are a major public health concern in the United States. Drugs that target the γ-aminobutyric acid or serotonergic system, such as benzodiazepines and selective serotonin reuptake inhibitors, respectively, are the most widely prescribed treatments for Cited by: Download Citation | Dopamine and Glutamate in Motor and Cognitive Symptoms of Parkinson’s Disease | Parkinson's disease (PD) is characterized by motor and cognitive deficits. The main motor. The role of glutamate in anxiety and related disorders Article Literature Review (PDF Available) in CNS spectrums 10(10) November with 3, Reads How we measure 'reads'. Glutamates are involved in epilepsy, schizophrenia and cognitive disorders (memory and learning). Monosodium Glutamate (MSG) is a natural salt of glutamic acid. MSG is used as a natural food additive to enhance flavors of industrialized food.